I just found out about this:
Sat, Oct 16, 2010 7:00P Admission is free but tickets are required.
Creator of The Simpsons, Futurama, and Life in Hell, Matt Groening is leaving an indelible mark on the popular culture of the United States and many other corners of the world.
This evening he'll discuss his career in comics and television with Tom Gammill, an acclaimed writer/producer/cartoonist, who has written for such programs as Seinfeld, Late Night with David Letterman, and The Simpsons. This conversation with Groening complements the talk by Art Spiegelman, the 2010–11 Wexner Residency Award artist in media arts, held the following afternoon.
More info here: http://www.wexarts.org/ed/index.php?eventid=4943
Here is info to get to the Wexner Center in Columbus: